(PMDD), formerly known as premenstrual syndrome (PMS). Symptoms of PMDD include mood problems such as anxiety, depression, irritability or persistent anger, mood swings, and tension. Physical problems that accompany PMDD include bloating, breast tenderness, headache, and joint and muscle pain. Symptoms typically begin 1 to 2 weeks before a woman’s menstrual period and are severe enough to interfere with day-to-day activities and relationships.
Fluoxetine is a member of the family of drugs called “selective serotonin re-uptake inhibitors.” Serotonin is one of the chemical messengers believed to govern moods. Ordinarily, it is quickly reabsorbed after its release at the junctures between nerves. Re-uptake inhibitors such as Fluoxetine slow this process, thereby boosting the levels of serotonin available in the brain.
The usual starting dose is 20 milligrams per day, taken in the morning. Your doctor may increase your dose after several weeks if no improvement is observed. People with kidney or liver disease, the elderly, and those taking other drugs may have their dosages adjusted by their doctor.
Dosages above 20 milligrams daily should be taken once a day in the morning or in 2 smaller doses taken in the morning and at noon.
The usual daily dose for depression ranges from 20 to 60 milligrams. For obsessive-compulsive disorder the customary range is 20 to 60 milligrams per day, though a maximum of 80 milligrams is sometimes prescribed. For bulimia nervosa, the usual dose is 60 milligrams, taken in the morning. Your doctor may have you start with less and build up to this dosage. The usual dose for premenstrual dysphoric disorder is 20 milligrams a day.
Switching to another medication or discontinuing this medication may involve slow reduction of this medication while the other is also being slowly introduced.